Structure, evolution and action of vitamin B-6-dependent enzymes

Authors
Jansonius, JN
Citation
Jn. Jansonius, Structure, evolution and action of vitamin B-6-dependent enzymes, CURR OP STR, 8(6), 1998, pp. 759-769
Citations number
59
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN STRUCTURAL BIOLOGY
ISSN journal
0959440X → ACNP
Volume
8
Issue
6
Year of publication
1998
Pages
759 - 769
Database
ISI
SICI code
0959-440X(199812)8:6<759:SEAAOV>2.0.ZU;2-2
Abstract
The number of known three-dimensional structures of vitamin B-6-dependent e nzymes has doubted in the past two years. A fourth type of fold for BG-depe ndent enzymes, involving a TIM-barrel domain, has been discovered. Alanine racemase is the first known representative of this new fold. Significant pr ogress has been made in understanding the allosteric effects in the tryptop han synthase reaction.