Three-dimensional structural studies on fragments of fibrinogen and fibrin

Authors
Doolittle, RF Spraggon, G Everse, SJ
Citation
Rf. Doolittle et al., Three-dimensional structural studies on fragments of fibrinogen and fibrin, CURR OP STR, 8(6), 1998, pp. 792-798
Citations number
51
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN STRUCTURAL BIOLOGY
ISSN journal
0959440X → ACNP
Volume
8
Issue
6
Year of publication
1998
Pages
792 - 798
Database
ISI
SICI code
0959-440X(199812)8:6<792:TSSOFO>2.0.ZU;2-Z
Abstract
Fibrinogen is a 340 kDa glycoprotein found in the blood plasma of all verte brates. It is transformed into a fibrin clot by the action of thrombin. Rec ent X-ray structures of core fragments of both fibrinogen and fibrin have r evealed many details about this polymerization event. These include structu res of a 30 kDa recombinant gamma C domain, an 86 kDa fragment D from human fibrinogen and a cross-linked double-D fragment from fibrin.