The clinical diagnosis of cardiac myxomas remains a challenge despite the a
dvent of echocardiographic technology. These tumors may produce a variety o
f clinical and laboratory findings that can mimic systemic disease and obsc
ure the proper diagnosis. Although histological benign, cardiac myxomas may
cause significant morbidity and mortality via intracardiac obstruction and
arterial embolism. Possible longterm sequelae may be avoided by early reco
gnition and prompt surgical excision. We briefly review the various finding
s associated with cardiac myxomas (nonfamilial and familial) with emphasis
on cutaneous presentations. An illustrative case of left atrial myxoma with
cutaneous findings contributing to the diagnosis is discussed. Certain ski
n lesions and multifocal clinical findings should alert the clinician to co
nsider cardiac myxoma in the differential diagnosis.