EXPERIMENTAL HELICOBACTER-PYLORI INFECTION IN ASSOCIATION WITH OTHER BACTERIA

We performed surgical treatment on normal ddY mice before Helicobacter pylori inoculation. The treatment was expected to obstruct bacterial how out of the stomach and increase the chance of bacterial attachment to the gastric epithelium in mice. The bacterial challenge induced in flammation in the stomach. H. pylori was recovered from the stomach th roughout the observation period. Lactobacilli and streptococci tended to relate to the increase in number of H. pylori recovered. Pretreatme nt with atropine was considered to confuse the gastric flora and affec t the number of H. pylori recovered. These results suggested that a ce rtain amount of time is necessary for H. pylori to contact with the ga stric epithelium and that the composition of flora is important for th e establishment of H. pylori infection.