Phosphotyrosine-protein-phosphatase and diabetic disorders. Further studies on the relationship between low molecular weight acid phosphatase genotype and degree of glycemic control

We have studied a new sample of 276 NIDDM patients from the population of P enne (Italy). Comparison of the new data with those of 214 diabetic pregnan t women from the population of Rome reported in a previous paper has shown that the pattern of association between low molecular weight acid phosphata se genotype and degree of glycemic control is similar in the two classes of diabetic patients. Among nonobese subjects the proportion of ACP1*A (the a llele showing the lowest enzymatic activity) is lower in diabetic patients with; high glycemic levels (mean value greater than 8.9 mmol/l) than in dia betic patients with a low glycemic level (mean value less than 8.9 mmol/l). Among obese subjects no significant association is observed between glycem ic levels and ACP1. Among nonobese subjects the concentration of f isoform of ACP1 is higher in patients showing a high glycemic level than in patients showing a low glyc emic level. No significant difference is observed for s isoform.