Intracerebroventricular injections of [Arg(8)]vasopressin (500 ng/rat) or e
ndothelin-l (70 ng/rat) into the right lateral ventricle induced rotation a
long the long axis of the body (barrel rotation) in rats. Losartan (10-200
mu g/rat), an angiotensin AT(1) receptor antagonist, also evoked barrel rot
ation, which was not inhibited by vasopressin and endothelin receptor antag
onists. However, barrel rotation was not observed after injections of high
doses of another angiotensin II receptor antagonist, [Sar(1),Ile(8)]angiote
nsin II (100 mu g/rat), or after angiotensin LT (10 mu g/rat). The results
indicate that losartan does evoke barrel rotation which may be not mediated
via vasopressin and endothelin receptors. (C) 1998 Elsevier Science B.V. A
ll rights reserved.