Effect of albendazole sulfoxide solution on the scolices and the hepatobiliary system

The use of scolocidal solutions in the hepatobiliary system may result in c austic sclerosing cholangitis. In this study, the effectivenes of a biologi cal metabolite of albendazole, albendazole sulfoxide, on scolices and the h epatobiliary system was evaluated. In the in vitro study, it was found that 100 mu g/ml albendazole sulfoxide solution had strong scolocidal effect in 15 min. In the in vivo study, two experimental groups, each consisting of 8 rabbits aged 3-4 months and weighing 2,500 +/- 250 g, 100 mu g/ml albenda zole sulfoxide and normal saline were given into the biliary tract. ALP, GG T, SGOT and SGPT values on days 7, 30 and 60 were not found to be significa ntly increased compared to preoperative values. Total bilirubin values were high in the working group 7 and 30 days postoperatively and on day 30 in t he control group, returning back to normal levels on day 60 in both groups. Histopathological evaluation of the liver parenchyma and the biliary syste m on day 60 revealed no differences between the groups. Consequently, alben dazole sulfoxide solution may be used intraoperatively for scolocidal purpo ses.