Synergistic cytotoxic effect of cisplatin and monoclonal anti-Fas IPO-4 antibodies on human epidermoid carcinoma cell line KB

Authors
Chekhun, VF Shishova, YV Yurchenko, OV Shlapatskaya, LN Mikhalap, SV Berdova, AG Sidorenko, SP Kulik, GI Gluzman, DF
Citation
Vf. Chekhun et al., Synergistic cytotoxic effect of cisplatin and monoclonal anti-Fas IPO-4 antibodies on human epidermoid carcinoma cell line KB, EXP ONCOL, 20(3-4), 1998, pp. 210-216
Citations number
20
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
EXPERIMENTAL ONCOLOGY
ISSN journal
02043564 → ACNP
Volume
20
Issue
3-4
Year of publication
1998
Pages
210 - 216
Database
ISI
SICI code
0204-3564(199809/12)20:3-4<210:SCEOCA>2.0.ZU;2-F
Abstract
Epidermoid carcinoma cell line KB shown by PAP-analysis to be positive for Fas-antigen and sensitive to Fas-mediated apoptosis. Monoclonal anti-Fas an tibody, IPO-4 (IgM), induced cell death in human epidermoid carcinoma cell line KB with the development of classic morphological features of apoptosis . Therapeutical agent cisplatin also was shown to induce apoptosis in KB ce lls with some morphological differences from Fas-mediated apoptosis. The pr esent study demonstrates that anti-Fas antibody in combination with cisplat in results In an enhanced cytotoxicity and synergy when tested against epid ermoid carcinoma cell line KB.