The influence of polyreactive antibodies on tumor cell proliferation

Mouse serum polyreactive antibodies (PRAB), which are able to interact with various serologically unrelated antigens, substantially influence the prol iferation of mouse L929 fibroblasts transformed by 3-methylcholanthrene. Ei ther short-time treatment of L929 cells with PRAB or their combined cultiva tion lead to suppression of density-dependent inhibition of growth. The qua ntity of giant cells did not differ from control, PRAB also is able to infl uence strongly the tumour development, induced by injection of Lewis carcin oma cells subcutaneously to C57BI mice. Preincubation of Lewis carcinoma ce lls by PRAB leads to a significant acceleration of tumour development in co mparison to control. Similar effect was challenged by intramuscle and/or su bcutaneous injection of PRAB to mice before or after injection of Lewis car cinoma cells.