The antitumor properties of the synthetic antioxidant emoxipine

Tumor growth inhibition (TGI) of the murine transplantable Ehrlich carcinom a (EC) and leukemia development induced by Rauscher leukemia virus (RVL) in mice under treatment of new synthetic antioxidant Emoxipin (EMP)[6-methyl- 2-ethyl-3-oxipyridine] have been studied. Hybrid mice Fi [C57BI x CBA] with s. c. EC (10(6) tumour cells/0.5 mi of medium 199) were treated i. m. with EMP doses of 0.04, 0.08, and 0.16 mg/kg for 20 days, per courses 0.72, 1.4 4, and 2.88 mg/kg. RVL infected (dilutions 10(-4) and 10(-5)) mice Balb/c w ere treated i. m. with EMP doses of 0.08 and 0.16 mg/kg accordingly. It was found that EMP with all used doses resulted in a moderate TGI at day 20. O n the 5th, and 10th days after treatment, the most pronounced TGI was achie ved (94 and 81%). It was shown also a significant inhibition of RVL-leukemi a development after the EMP injection with the total doses of 1.04 and 1.2 mg/kg. At the same time, similar action of EMP (the total dose 1,2 mg/kg) w as observed with sodium nitrite stimulating viral blastomogenesis.