Murine L1210 leukemia cells resistant to cis-diaminedichloroplatinum(II) action are also refractory to beta 1-induced growth inhibition

Authors
Stoika, RS Yakymovych, MY Yakymovych, IA Shishova, YV Chekhun, VF
Citation
Rs. Stoika et al., Murine L1210 leukemia cells resistant to cis-diaminedichloroplatinum(II) action are also refractory to beta 1-induced growth inhibition, EXP ONCOL, 20(3-4), 1998, pp. 256-258
Citations number
14
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
EXPERIMENTAL ONCOLOGY
ISSN journal
02043564 → ACNP
Volume
20
Issue
3-4
Year of publication
1998
Pages
256 - 258
Database
ISI
SICI code
0204-3564(199809/12)20:3-4<256:MLLCRT>2.0.ZU;2-7
Abstract
Murine L1210 leukemia cells possessing an increased resistance to cis-diami nedichloroplatinum (II) (cDDP) were found to be refractory to the transform ing growth factor (TGF) beta 1-induced growth inhibition, while the parenta l L1210 cells were strongly inhibited by this cytokine. Growth inhibition w as estimated on the basis of H-3-thymidine incorporation and direct cell co unting. These results suggest the existence of cross-resistance to cDDP and TGF-beta 1 in the studied leukemia cells.