A novel synthetic route to a 5-CnF2n+1-substituted uracil 4 involves coupli
ng of 5-bromo-2,4-diethoxypyrimidine (2) with CnF2n+1I in the presence of c
opper bronze followed by acid hydrolysis of the resultant product 3. Hydrol
ysis of 4 in aqueous NaOH furnishes a Cn-1F2n-1-carbonyl-substituted uracil
7 in high yield.