A hard wired model of coupled frontal working memories for various tasks

The majority of previous models of working memory CWM), rule production and strategy decisions have not taken into account the known anatomy of the hu man brain. Here, a simple hard wired neural network is developed which inve stigates the role of the dorsolateral prefrontal cortex (DLPFC), the ventro lateral prefrontal cortex (VL) and the Anterior Cingulate Gyrus (ACG), toge ther with their associated basal ganglia-thalamocortical loops, in solving the classical delayed response task (DRS), Delayed visual matching (DRO) an d the Wisconsin card sorting task (WCST). This is done by constraining the model by some of the known connectivity within these areas. Lesions are als o applied to the model thereby providing possible interpretations for some of the deficits observed in various kinds of patients while performing thos e tasks. (C) 1999 Elsevier Science Inc. All rights reserved.