Methoxamine is an alpha-adrenergic drug, its unique pharmacokinetics and me
chanism of action on alpha-1 receptors lead to consider it, similarly to ph
enylephrine, as a first-choice drug for treating drug-induced or veno-occlu
sive priapism. The experience obtained with its use in the management of th
ree cases of priapism lasting over 7 h and one case of sustained rigid erec
tion caused during anesthetic induction are reported.