P. Espandiari et al., Promoting activity of the herbicide dicamba (2-methoxy-3,6-dichlorobenzoicacid) in two stage hepatocarcinogenesis, INT J ONCOL, 14(1), 1999, pp. 79-84
Our goal was to examine whether dicamba, a widely-used broad leaf herbicide
, has promoting activity in two-stage hepatocarcinogenesis. Female Sprague
Dawley rats were given a single dose of diethylnitrosamine and then diets c
ontaining dicamba, or phenobarbital, or both for six months. The number and
volume of placental glutathione-S-transferase-positive, glucose-6-phosphat
ase-negative or ATPase-negative foci were quantified in the liver. Dicamba
alone did not increase the number or volume of these altered hepatic foci.
Dicamba did, however, show a significant effect on the number or volume of
certain markers in animals also treated with phenobarbital. These data show
that dicamba in combination with other promoters may have weak promoting a
ctivity in two-stage hepatocarcinogenesis in the rat.