Carbohydrate supplementation and the lymphocyte proliferative response to long endurance running

Citation
Da. Henson et al., Carbohydrate supplementation and the lymphocyte proliferative response to long endurance running, INT J SP M, 19(8), 1998, pp. 574-580
Citations number
39
Categorie Soggetti
Medical Research General Topics
Journal title
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
ISSN journal
01724622 → ACNP
Volume
19
Issue
8
Year of publication
1998
Pages
574 - 580
Database
ISI
SICI code
0172-4622(199811)19:8<574:CSATLP>2.0.ZU;2-Q
Abstract
This randomized, double-blind, placebo-controlled study examined the influe nce of 6% carbohydrate ingestion on hormonal and lymphocyte proliferative r esponses (5 total samples over 9 hours) to 2.5 h of high-intensity running by 30 experienced marathon runners. The T-cell response differed between gr oups, with the placebo group exhibiting a greater increase immediately post -run and greater decrease at 3 h of recovery. No group differences were obs erved for Con A-, PHA-, or PWM-induced lymphocyte proliferation. However, w hen PHA was adjusted per T-cell, group differences were observed, highlight ed by a decrease in the placebo group immediately post-run. Glucose and cor tisol responses differed between groups, with glucose lower and cortisol hi gher in the placebo group immediately post-run, post-run glucose correlated negatively with post-run cortisol (r = - 0.670, P < 0.001) and epinephrine (r= - 0.540, P=0.002). Post-run cortisol also correlated negatively with t otal lymphocytes and T-cells at 1.5 hours (r= - 0.429, P = 0.018 and r= - 0 .424, P = 0.019, respectively) and 3 hours (r= - 0.566, P=0.001 and r=-0.52 3, P=0.003, respectively) of recovery. The pre- to post-run change in gluco se correlated to the same changes in PHA/T-cell (r= 0.456, P = 0.011). The data support an interactive effect of carbohydrate ingestion on plasma gluc ose and cortisol. The data support an interactive effect of carbohydrate in gestion on plasma glucose and cortisol, T-cell trafficking. and cell-adjust ed PHA-induced lymphocyte proliferation following long endurance running.