Antioxidative phenolic compounds from sage (Salvia officinalis)

Ten phenolic compounds were isolated from a butanol fraction of sage extrac ts. Their structures were determined by spectral methods (NMR, MS, IR). Amo ng them, a novel compound, 4-hydroxy-acetophenone-4-O-beta-D-apiofuranosyl- (1-->6) was identified. Two test systems, DPPH free radical scavenging acti vity and radical cation ABTS(.+) scavenging activity, were used to evaluate their antioxidant activity. The most active compounds were found to be ros marinic acid and luteolin-7-O-beta-glucopyranoside.