NEUROTROPHIN-3-LIKE IMMUNOREACTIVITY AND TRK-C EXPRESSION IN HUMAN SPINAL MOTONEURONS IN AMYOTROPHIC-LATERAL-SCLEROSIS

Authors
DUBERLEY RM JOHNSON IP ANAND P LEIGH PN CAIRNS NJ
Citation
Rm. Duberley et al., NEUROTROPHIN-3-LIKE IMMUNOREACTIVITY AND TRK-C EXPRESSION IN HUMAN SPINAL MOTONEURONS IN AMYOTROPHIC-LATERAL-SCLEROSIS, Journal of the neurological sciences, 148(1), 1997, pp. 33-40
Citations number
40
Categorie Soggetti
Neurosciences
Journal title
Journal of the neurological sciences → ACNP
ISSN journal
0022510X
Volume
148
Issue
1
Year of publication
1997
Pages
33 - 40
Database
ISI
SICI code
0022-510X(1997)148:1<33:NIATEI>2.0.ZU;2-S
Abstract
We have demonstrated neurotrophin-3 (NT-3) like immunoreactivity and t yrosine kinase C (Trk C) receptor expression in motoneurones in postmo rtem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones i s decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS. (C) 1 997 Elsevier Science B.V.