Hg. Neumann et al., Changes in the classification of carcinogenic chemicals in the work area -(Section III of the German List of MAK and BAT values), J CANC RES, 124(12), 1998, pp. 661-669
Carcinogenic chemicals in the work area were previously classified into thr
ee categories in section III of the German List of MAK and BAT values (the
list of values on maximum workplace concentrations and biological tolerance
for occupational exposures). This classification was based on qualitative
criteria and reflected essentially the weight of evidence available for jud
ging the carcinogenic potential of the chemicals. In the new classification
scheme the former sections IIIA1, IIIA2, and IIIB are retained as categori
es 1, 2, and 3, to correspond with European Union regulations. On the basis
of our advancing knowledge of reaction mechanisms and the potency of carci
nogens, these three categories are supplemented with two additional categor
ies. The essential feature of substances classified in the new categories i
s that exposure to these chemicals does not contribute significantly to the
risk of cancer to man, provided that an appropriate exposure limit (MAK va
lue) is observed. Chemicals known to act typically by non-genotoxic mechani
sms, and for which information is available that allows evaluation of the e
ffects of low-dose exposures, are classified in category 4. Genotoxic chemi
cals for which low carcinogenic potency can be expected on the basis of dos
e/response relationships and toxicokinetics and for which risk at low doses
can be assessed are classified in category 5. The basis for a better diffe
rentiation of carcinogens is discussed, the new categories are defined, and
possible criteria for classification are described. Examples for category
4 (1,4-dioxane) and category 5 (styrene) are presented.