Convenient synthesis of 2,6-di-tert-butyl-4-[5-(3-pyridyl)-4-oxapentyl]phenols and their thia-analogues

Authors
Pugovics, O Kauss, V Kalvinsh, I Gold, MR Quack, G
Citation
O. Pugovics et al., Convenient synthesis of 2,6-di-tert-butyl-4-[5-(3-pyridyl)-4-oxapentyl]phenols and their thia-analogues, J CHEM R-S, (8), 1998, pp. 430-432A
Citations number
13
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
8
Year of publication
1998
Pages
430 - 432A
Database
ISI
SICI code
0308-2342(199808):8<430:CSO2>2.0.ZU;2-#
Abstract
A convenient large scale procedure for the synthesis of Nicanartine {2,6-di -tert-butyl-4-[5-(3-pyridyl)-4-oxapentyl]phenol}, an antiatherosclerotic co mpound has been developed, the synthetic route towards the thia-analogue as well as various branched-chain oxa- and thia-derivatives of the parent com pound has also been investigated.