Tuberous sclerosis complex and neonatal seizures

Tuberous sclerosis complex is a multisystemic neurocutaneous disorder, mani festing variably during infancy and childhood that remains poorly described in neonates. When described ipl this population, tuberous sclerosis comple x is most commonly associated with cardiac rhabdomyomas and brain tumors, b ut is rarely mentioned as an etiology for neonatal seizures. We report two children with tuberous sclerosis presenting for neonatal seizures. Neuroima ging findings of neonatal tuberous sclerosis complex are discussed. Given t he absence of many of the traditional stigmata of tuberous sclerosis comple x in the neonate, seizures should be considered an important presenting fea ture of this disorder in this particular age group.