Md. Waldinger et al., EJACULATION-RETARDING PROPERTIES OF PAROXETINE IN PATIENTS WITH PRIMARY PREMATURE EJACULATION - A DOUBLE-BLIND, RANDOMIZED, DOSE-RESPONSE STUDY, British Journal of Urology, 79(4), 1997, pp. 592-595
Objective To compare the influence of a daily dose of 20 or 40 mg of t
he serotonergic antidepressant drug paroxetine in delaying ejaculation
in patients with primary premature ejaculation. Patients and methods
Thirty-four patients with primary premature ejaculation were randomly
assigned to receive 20 mg or 40 mg daily of paroxetine for 7 weeks in
a double-blind fixed-dose trial after an initial dose of 20 mg/day in
the first week. Patients and their female partners were interviewed se
parately. In the group receiving 20 mg, one of two capsules consisted
of placebo and in the group receiving 40 mg, both capsules contained a
ctive drug. Results The trial was completed by 27 men; both groups sho
wed a statistically significant difference from the baseline values of
ejaculation latency (P<0.001) and a clinically relevant improvement i
n ejaculation time. The increase in the intravaginal ejaculation laten
cy time was not statistically significant different between the groups
. The patient's assessments were confirmed independently by their part
ners. Conclusions The daily use of 20 mg paroxetine may be considered
as an adequate treatment for primary premature ejaculation. Increasing
the dose may lead to a further increase in ejaculation latency.