Half mustard (CEES) induced damage to rabbit cornea: Attenuating effect oftaurine-pyruvate-alpha-ketoglutarate-pantothenate mixture

Studies have been conducted on the corneal damage by half mustard (2-chloro ethyl-ethyl sulfide, GEES) and its possible prevention by a mixture of taur ine, alpha-ketoglutarate, pyruvate and pantothenate. GEES has been found to damage the membrane permeability function of the corneal epithelium as evi denced by increased flux of the rubidium ion from the epithelial to the end othelial side. The cornea also loses its transparency. These damaging effec ts are preventable by the above mixture labeled as VM. It is conceived that use of such a mixed formulation may provide a pharmacological means of pro phylactic and post-exposure treatment against the tissue damage caused by e xposure to the mustards.