This paper presents a psychological perspective on key issues related to me
dical vocabularies, There have been rapid advances in the development of co
mputer technology underlying medical information systems. However, in keepi
ng with technological progress, we must also take into account advances in
our understanding of human behaviour and learn from failures in human perfo
rmance. A central issue examined in this paper is the extent to which we ca
n develop generic vocabularies that are also flexible and adaptable to spec
ific situations. Empirical research indicates that variability in human per
formance is much greater than what current medical classifications take int
o account. A related challenge is that of how to best develop vocabularies
that meet the needs of users. Based on theoretical perspectives and researc
h emerging from the domain of cognitive psychology, we suggest that an unde
rstanding of the cognitive mechanisms underlying the comprehension and appl
ication of terminology is required. It is argued that rather than beginning
with highly specified terminologies, i.e, the normative approach, we might
instead begin by examining the natural context of how health care workers
acquire, understand and negotiate knowledge in practice.