Leishmaniasis is a recurrent health problem for the U.S. and other militari
es. Health care workers may be unfamiliar with the risk factors, transmissi
on, clinical features, diagnosis, and treatment of this disease. A team of
highly trained specialists is required to properly manage service members w
ith leishmaniasis. Such care is available only in a few medical centers. Al
though there are no prophylactic drugs to prevent this disease, control of
insect populations and use of personal protection measures can minimize art
hropod-related casualties. The impact of leishmaniasis on military operatio
ns and research initiatives to better prevent, diagnose, and treat infectio
n are discussed.