SIMILAR CAPACITY OF CLONOGENIC HEMATOPOIE TIC-CELLS (CFU-S-11) FROM THE LIVER AND PERIPHERAL-BLOOD OF ADULT MICE FOR SELF-MAINTENANCE

The capacity of CFU-S-11, which formed colonies in the spleen on day 1 1 after transplantation to an irradiated recipient for self-maintenanc e, was studied. The indices for self-renewal of individual CFU-S from the spleen, bone marrow, and peripheral blood were compared in the sam e sexually mature donor mice by retransplanting the colonies isolated from the spleen parenchyma to secondary recipients. The number of seco ndary CFU-S-11 per primary CFU-S-11 originating from the liver hardly differed from that originating from the peripheral blood, but is almos t twice less than for the bone marrow CFU-S-11. The conclusion was dra wn that compartment CFU-S of the liver of adult animals contains the c ells migrating from blood flow, which, apparently, are not dormant emb ryonic cells.