Fever as presenting symptom of multiple myeloma

We describe a GX-year-old patient presenting with recurrent fever, who even tually turned out to suffer from multiple myeloma. He was treated with Vinc ristine, Doxorubicin and Dexamethasone combination chemotherapy and interme diate dose Melphalan (70 mg/m(2)), respectively. Apart from periods of feve r due to sepsis following chemotherapy, the recurrent fever disappeared aft er response, but recurred synchronously with progression of the disease. Re current fever in this case should be considered as a symptom of active mult iple myeloma. This form of presentation of multiple myeloma has been descri bed in literature only a few times. (C) 1998 Elsevier Science B.V. All righ ts reserved.