Post-transplantation lymphoproliferative disorder of the T-cell/B-cell type: An unusual manifestation in a renal allograft

Marked impairment of the cellular immune system predisposes renal transplan t recipients to Epstein-Barr virus (EBV) associated clinical syndromes. Thi s can culminate in post-transplantation lymphoproliferative disorders (PTLD ) and malignant lymphomas. An unusual PTLD in a 59-year-old renal transplan t recipient is reported here. Sonography and CT scan revealed a hypovascula r infiltrating tumor mass in the lower pole of the graft which on histopath ologic examination revealed a monotonous lymphoid proliferation. T-cell rec eptor and immunoglobulin heavy chain gene rearrangement as well as immunohi stochemical analyses demonstrated a polyclonal origin of atypical lymphatic T- and B-cells. The Epstein-Barr viral genome was detected in the mass by Southern blot analysis, and a primary EBV infection was confirmed by serolo gic studies. Clinical follow-up showed a tumor-free course till the patient 's sudden cardiac death 14 months after the operation.