Effect induced by interleukin-1 on the behaviour of B16F10 melanoma cells

We have previously demonstrated that in vitro treatment with interleukins ( IL-2 and IL-6) enhances metastasis in B16 murine melanoma. IL-I has been re ported to be involved in the metastatic activity of human melanoma; so in t he present study we have investigated if IL-I could also modulate the behav iour of this experimental tumor. Data showed that low doses of IL-1 induced cell proliferation and several modifications in the expression of MHC anti gens, fibronectin and laminin, however these changes did not lead to a high er metastatic efficiency. In addition it was shown that B16F10 cells expres s IL-1 beta mRNA. It can be concluded that IL-l may be involved in the biol ogy of B16F10 cells although its role in metastasis needs further investiga tion.