Conjunctival epithelium expression of HLA-DR in dry eye patients

Purpose: To compare conjunctival epithelium expression of HLA-DR and ICAM-1 with tear dynamics and ocular surface parameters. Methods: Brush cytology and flow cytometry were used to quantitatively analyze HLA-DR and ICAM-1 ex pression in 28 dry eye patients, Results: HLA-DR was expressed in 66% of th e conjunctival cells of dry eye patients. This expression correlates with t hat of ICAM-1, as well as with the Schirmer test results (p < 0.05). Conclu sion: This study confirmed that dry eye consists not only of ocular surface desiccation, but also of upregulation of the HLA-DR and ICAM-1 molecule in the conjunctival epithelium, possibly resulting in increased inflammation.