Lymphatic mapping allows the surgeon to identify and remove the first drain
ing (sentinel) lymph node from a primary melanoma with minimal morbidity. T
he procedure facilitates accurate staging and identification of patients in
need of additional therapy. We used lymphatic mapping and sentinel lymph n
ode biopsy in two children with melanoma. Both patients had evidence of met
astatic melanoma in their sentinel lymph nodes and underwent regional lymph
adenectomy, Malignant melanoma and atypical pigmented lesions in children r
emain diagnostically challenging for the pathologist and clinician. Misdiag
noses occur, and the correct interpretation of a melanocytic tumor is too o
ften made only after recurrence or metastasis has occurred. The use of lymp
hatic mapping facilitates accurate staging and identifies children in whom
additional therapy may be indicated. In addition, it can assist in the asse
ssment of the biologic potential of a difficult lesion.