We discuss the morphology and substructure in clusters of galaxies and thei
r relation to large scale structures such as filaments. As predicted by num
erical simulations, the small scale structures in clusters are co-aligned w
ith the much larger filamentary structures in which the clusters are embedd
ed and from which they formed. For regular clusters, we review the potentia
l of X-ray observations to derive gravitating masses to large radii. Using
a small sample of observations, we show that the baryon fraction rises to a
typical value of about 25% which, in the standard Big Bang scenario, argue
s for a low value of Omega. We briefly indicate the potential for future X-
ray studies of clusters with AXAF, XMM, and SRG.