New developments in antibiotic pharmacology

New in vitro models: Numerous posters at the ICAAC were devoted to in vitro models simulating plasma kinetics, including many concerning new molecules , especially fluoroquinolones. Gatifloxacine, for example, has been found t o be very active against Gram positive and intracellular germs. The performance of clinafloxacine against Gram negatives was also announced . Moxifloxacine was studied with a novel dynamic in vitro model against pen icillin-resistant Streptococcus pneumoniae. In this model, the bactericidal effect was very rapid and complete, with no regrowth. Advances in the preclinical phase: There was much discussion concerning in vitro models and experimental infections which are being used to further ac celerate preclinical investigations of new compounds. Presse Med 1998; 27:S 51-4 (C) 1998, Masson, Paris.