Midazolam via the intranasal route: an effective rescue medication for severe epilepsy in adults with a learning disability

People with a learning disability are often disadvantaged due to the nature of their disability. Up to a third are likely to have concomitant epilepsy which adds to the health loss experienced by this group. It is important t o manage their epilepsy in such a way as to limit the debilitating effects of both the illness and the medication. Rectal diazepam remains the gold st andard rescue medication for prolonged, recurrent seizures or seizures asso ciated with hypoxia. Some of the drawbacks are highlighted in this paper an d we go on to explore a novel means of treating these seizures. Midazolam, via the intranasal route, has been used extensively in children, mostly as a sedative but also in the treatment of epilepsy. We present two cases, bot h are adults with a learning disability, who have benefited significantly f rom the use of intranasal midazolam. Ongoing research into the safe use of this form of treatment, training of staff and carers and the impact on the individual is being conducted.