Preparation of asymmetric bilayer-vesicles with inner and outer monolayerscomposed of different amphiphilic molecules

Citation
Zd. Xiao et al., Preparation of asymmetric bilayer-vesicles with inner and outer monolayerscomposed of different amphiphilic molecules, SUPRAMOL SC, 5(5-6), 1998, pp. 619-622
Citations number
17
Categorie Soggetti
Multidisciplinary
Journal title
SUPRAMOLECULAR SCIENCE
ISSN journal
09685677 → ACNP
Volume
5
Issue
5-6
Year of publication
1998
Pages
619 - 622
Database
ISI
SICI code
0968-5677(199810/12)5:5-6<619:POABWI>2.0.ZU;2-8
Abstract
Asymmetric vesicles were prepared layer by layer from reverse micelles. The aqueous solution was first entrapped into reverse micelles prepared from l ipid, then these reverse micelles penetrated the monolayer formed by anothe r kind of amphiphilic agent at organic solvent/water interface by centrifug ation and were assembled spontaneously by the second layer to form asymmetr ic vesicles. In general, the diameters of the vesicles ranged from 30 to 10 0 nm. A fluorescein quenching experiment showed that asymmetric vesicles wi th the inner layer being lipid and the outer layer being single-chain amphi philic molecules, [(bpy)(2) Ru(diazafluorenone) (CH2)(15)CH3](PF6)(2), were successfully prepared. The half-life of flip-flop of the amphiphilic molec ules between inner and outer layers was estimated to be about 17 days. (C) 1998 Elsevier Science Limited. All rights reserved.