Conformation-driven computing: simulating the context-conformation-action loop

Function follows conformation in biological macromolecules. In general ther e are a number of possible conformational states. Which state is favored is determined by physicochemical contest. The fusion of the features that com prise this context to form a particular conformational state is at the core of cellular control and biological information processing. We have develop ed a simulation system to investigate the information processing capabiliti es of networks of context-sensing macromolecules (to be illustrated by a si mple example). (C) 1998 Elsevier Science Limited. All rights reserved.