We report herein the unusual case of a 66-year-old woman found to have aden
ocarcinoma arising in a tailgut cyst. The patient had been observed for 6 m
onths following the discovery of a presacral cystic mass measuring 10 x 9 c
m for which she had refused surgery. The serum tumor marker, carcinoembryon
ic antigen, became slightly elevated, and diagnostic imaging distinctly rev
ealed a tumorous lesion with papillary projection into the cyst lumen. The
cystic mass was then excised through the transsacral approach. The patholog
ical findings were compatible with moderately differentiated adenocarcinoma
arising in a tailgut cyst. This entity is extremely rare, and only six cas
es, including our own, have been reported in the English literature. Early
complete excision is advised because it is almost impossible to determine f
or certain whether presacral cystic masses are benign or malignant prior to
surgery.