2H-pyran-2-ones as synthons for (E)-alpha,beta-didehydroamino acid derivatives

Authors
Vranicar, L Polanc, S Kocevar, M
Citation
L. Vranicar et al., 2H-pyran-2-ones as synthons for (E)-alpha,beta-didehydroamino acid derivatives, TETRAHEDRON, 55(1), 1999, pp. 271-278
Citations number
30
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
1
Year of publication
1999
Pages
271 - 278
Database
ISI
SICI code
0040-4020(19990101)55:1<271:2ASF(A>2.0.ZU;2-G
Abstract
2H-Pyran-2-ones with the defined (E)-structure of a alpha,beta-didehydroami no acid unit were used as synthons for a series of configurationally stable (E)-alpha,beta-didehydroamino acid derivatives containing a benzoyl protec ted amino function and a pyrazolyl residue, They were derived from 2H-pyran -2-ones and hydrazines under various reaction conditions. A possibility of the formation of (Z)-isomers from the above-mentioned precursors is also di scussed. (C) 1998 Elsevier Science Ltd. All rights reserved.