Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): Mechanisms of action

Authors
Lazarus, AH Freedman, J Semple, JW
Citation
Ah. Lazarus et al., Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): Mechanisms of action, TRANSFUS SC, 19(3), 1998, pp. 289-294
Citations number
34
Categorie Soggetti
Hematology
Journal title
TRANSFUSION SCIENCE
ISSN journal
09553886 → ACNP
Volume
19
Issue
3
Year of publication
1998
Pages
289 - 294
Database
ISI
SICI code
0955-3886(199809)19:3<289:IIAAII>2.0.ZU;2-J
Abstract
Infusion of large amounts of intravenous immunoglobulin (MG) or anti-D can reverse the low platelet count in patients with ITP within hours of the ini tiation of treatment. In some cases, the effects of IVIG appear to far outl ast several half-lives of the product. Several mechanisms have been propose d to explain these rapid and long term effects and these will be discussed in this review. (C) 1998 Elsevier Science Ltd. All rights reserved.