Antisocial personality disorder and alcohol-induced aggression

This study compared the effects of alcohol on aggressive responding between subjects with antisocial personality disorder (ASPD) and subjects without ASPD, Eighteen alcohol drinking subjects (10 subjects without ASPD and 8 su bjects with ASPD) underwent testing on a laboratory measure of aggression, the Point Subtraction Aggression Paradigm, after consumption of placebo and three doses of alcohol (0.25 g/kg, 0.5 g/kg, and 1.0 g/kg), There was a si gnificant difference in the effect of alcohol on aggressive responding on t he Point Subtraction Aggression Paradigm between subjects with ASPD and sub jects without ASPD, Subjects with ASPD had a greater increase in aggressive responding after alcohol, compared with non-ASPD subjects. There was no di fference between the two groups in the effect of alcohol on monetary-reinfo rced responding.