Hindered rotation of CH3 groups and phenyl ring in clofibric acid (drug) studied by Cl-35-NQR and H-1-NMR spectroscopy

Authors
Nogaj, B Wasicki, J Mendlikowska-Humerczyk, M Glaser, A Utrecht, R
Citation
B. Nogaj et al., Hindered rotation of CH3 groups and phenyl ring in clofibric acid (drug) studied by Cl-35-NQR and H-1-NMR spectroscopy, APPL MAGN R, 15(2), 1998, pp. 227-236
Citations number
13
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
APPLIED MAGNETIC RESONANCE
ISSN journal
09379347 → ACNP
Volume
15
Issue
2
Year of publication
1998
Pages
227 - 236
Database
ISI
SICI code
0937-9347(1998)15:2<227:HROCGA>2.0.ZU;2-8
Abstract
The Cl-35-NQR frequency (v(Q)), nuclear quadrupole spin-lattice relaxation time (T-1Q), H-1-NMR second moment (M-2), nuclear magnetic spin-lattice rel axation time (T-1) and spin-lattice relaxation time in rotating frame (T-1 rho) were measured for polycrystalline clofibric acid (drug) as a function of temperature. Hindered rotation of two dynamically inequivalent methyl gr oups and the phenyl ring was detected, the relevant activation energies wer e determined. The rotations are discussed in detail.