Individuals who become clinically depressed once are more likely than are t
heir never-depressed counterparts to experience a future episode of depress
ion. This finding suggests that there is a stable vulnerability factor, or
set of factors, that predisposes some individuals to become depressed repea
tedly over the course of their lives. Cognitive theories of depression (e.g
., Beck, 1967, 1976) contend that negatively biased information processing
may constitute such a vulnerability factor for the onset and/or maintenance
of depression. In this paper, we review research using information-process
ing paradigms that examines depression-associated biases in attention to, a
nd memory for, negative information. We conclude that there is strong evide
nce that depression is associated with concurrent information-processing bi
ases. Moreover, based on the results of recent priming studies, we argue fu
rther that some aspects of cognitive functioning, particularly those involv
ing memory processes, may indeed represent a vulnerability factor for depre
ssion. We conclude this paper with a discussion of implications of this lin
e of research for the prevention and treatment of depression.