Genetic analysis of dystrophic cardiac calcification in DBA/2 mice

Authors
van den Broek, FAR Bakker, R den Bieman, M Fielmich-Bouwman, AXM Lemmens, AG van Lith, HA Nissen, I Ritskes-Hoitinga, JM van Tintelen, G van Zutphen, LFM
Citation
Far. Van Den Broek et al., Genetic analysis of dystrophic cardiac calcification in DBA/2 mice, BIOC BIOP R, 253(2), 1998, pp. 204-208
Citations number
18
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
253
Issue
2
Year of publication
1998
Pages
204 - 208
Database
ISI
SICI code
0006-291X(199812)253:2<204:GAODCC>2.0.ZU;2-S
Abstract
A DBA/2 x D2B6F(1) backcross was produced in order to study the genetic bac kground of pathological soft tissue calcification in the mouse. Calcificati on was assessed in the myocardium, kidney and tongue. Significant co-segreg ation was found with the genotype of microsatellite markers on the proximal end of Chromosome 7. This region contains a candidate gene, Hrc, coding fo r the histidine-rich calcium binding protein in the sarcoplasmatic reticulu m. The results support the hypothesis that the gene previously reported to be responsible for DCC (dystrophic cardiac calcification) in C3H mice (1) c auses generalized soft tissue calcification in DBA/2 mice. (C) 1998 Academi c Press.