Citation
Sh. Hu et Lp. Hager, Unusual propargylic oxidations catalyzed by chloroperoxidase, BIOC BIOP R, 253(2), 1998, pp. 544-546
Citations number
38
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X
→ ACNP
Volume
253
Issue
2
Year of publication
1998
Pages
544 - 546
Database
ISI
SICI code
0006-291X(199812)253:2<544:UPOCBC>2.0.ZU;2-W
Abstract
This paper describes a new chloroperoxidase oxidative activity, namely, pro
pargylic oxidations. Under appropriate conditions, chloroperoxidase catalyz
es the oxidation of a variety of 2-alkynes to aldehydes via alcohol interme
diates. Both hydrogen peroxide and t-butyl hydroperoxide can serve as termi
nal oxidants. The triple bond in the substrate is usually untouched. A free
radical mechanism is proposed for the initial hydroxylation step in the ov
erall reaction. (C) 1998 Academic Press.