Diagnostic value of troponin T in neonates of mild pre-eclamptic mothers

The measurement of myocardial damage by newer, highly specific markers of m yocardial damage is now possible, including cardiac structural proteins suc h as troponin T (TnT). in neonates of pre-eclamptic mothers, it identifies minor myocardial damage missed by other biochemical markers. The present st udy was designed to determine the diagnostic value of TnT concentrations in neonates of pre-eclamptic mothers. Fifteen neonates of pre-eclamptic mothe rs were studied (9 boys and 6 girls), and 17 healthy full-term neonates (9 boys and 8 girls) were selected as a control group. The serum TnT concentra tion in neonates of pre-eclamptic mothers (0.70 ng/ml) was significantly hi gher than that in the control group (0.10 ng/ml). in an echocardiographic s tudy, the mean mitral peak velocity at an atrial contraction (A) value of 3 9 cm/s in neonates of pre-eclamptic mothers was significantly lower than th at in the control group (53 cm/s), and the mean mitral peak velocity of ear ly diastole to peak velocity of the atrial contraction (E/A) value (1.75) i n neonates of pre-eclamptic mothers was significantly higher than that in t he control subjects (1.23). In conclusion, our study demonstrated high leve ls of cardiac TnT, lower mitral A values and high mitral E/A values in neon ates of pre-eclamptic mothers, presumably associated with mild myocardial d amage in the neonates of pre-eclamptic mothers.