New nuclear data are required for improved neutron and proton radiothe
rapy treatment planning as well as future applications of high energy
particle accelerators. Modern neutron radiotherapy employs energies ex
tending to 70 MeV, while industrial applications such as transmutation
and tritium breeding may generate neutrons exceeding energies of 100
MeV. Secondary neutrons produced by advanced proton therapy facilities
can have energies as high as 250 MeV. Each use requires nuclear data
for transport calculations and analysis of radiation effects (dosimetr
y). The nuclear data needs supportive of these applications are discus
sed, including the different information requirements. As data in this
energy region are sparse and likely to remain so, advanced nuclear mo
del calculations can provide some of the needed information. In this c
ontext new evaluated nuclear data are presented for C, N, and O. Addit
ional experimental information, including integral and differential da
ta, are required to confirm these results and to bound further calcula
tions. The required new data to be measured and the difficulties in ca
rrying out such experiments are indicated.