Jumping translocations of 3q in acute promyelocytic leukemia

Jumping translocation is a rare phenomenon, seldom reported to occur in can cer. A complex four-way translocation involving chromosomes 3, 9, 15, and 1 7 was identified in the chromosome study on a patient with a history of an acute promyelocytic leukemia (APL). In the follow-up studies, the same comp lex rearrangement exhibited a jumping translocation between chromosomes 3 a nd 9 in one clone and 3 and 6 in another clone. This is the first reported case of jumping translocation in APL. (C) Elsevier Science Inc., 1998.