Increased karyotype precision using fluorescence in situ hybridization andspectral karyotyping in patients with myeloid malignancies

We studied seven patients with various malignant hematologic disorders usin g fluorescence in situ hybridization (FISH) and one of these patients with spectral karyotyping (SKY). With appropriate probes, the t(8;21) and inv(16 ) were confirmed in two patients and the karyotypic precision was increased in five others using FISH and SKY. Two of three patients with 12p rearrang ements had a deletion of one TEL allele. Thus, these newer techniques ore a n important adjunct to accurate chromosome analysis in malignancy. (C) Else vier Science Inc., 1998.