Role of superoxide dismutase in ischemic brain injury: A study using SOD-1transgenic mice

Authors
Kinouchi, H Kamii, H Mikawa, S Epstein, CJ Yoshimoto, T Chan, PH
Citation
H. Kinouchi et al., Role of superoxide dismutase in ischemic brain injury: A study using SOD-1transgenic mice, CELL MOL N, 18(6), 1998, pp. 609-620
Citations number
33
Categorie Soggetti
Neurosciences & Behavoir
Journal title
CELLULAR AND MOLECULAR NEUROBIOLOGY
ISSN journal
02724340 → ACNP
Volume
18
Issue
6
Year of publication
1998
Pages
609 - 620
Database
ISI
SICI code
0272-4340(199812)18:6<609:ROSDII>2.0.ZU;2-E
Abstract
1. Nitric oxide radicals (NO) play an important role in the pathophysiology of focal cerebral ischemia. 2. Vascular NO can reduce ischemic brain injury by increasing CBF, whereas neuronal NO may mediate neurotoxicity following brain ischemia, mainly by i ts reaction with superoxide to generate peroxynitrite. 3. These findings could contribute to a strategy for the treatment of cereb ral ischemia.