Day-night differences of trigeminal chemosensitivity were investigated in 1
8 healthy volunteers employing both pain-related cortical potentials and pa
in ratings in response to stimulation of the nasal mucosa with CO2. Day-nig
ht differences were found with N1P2 amplitudes, P2 latencies and pain ratin
gs. It is concluded that the time of the day must not be ignored when human
chemosensitivity is investigated at suprathreshold levels.